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Other / General

Chronic fatigue (after workup)

3 plants

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If you have not looked for apnea, anemia, and depression, do not open an adaptogen. See metabolic-fatigue.

Primary plants

  1. Ashwagandha (Withania somnifera)
    1
    AshwagandhaHuman data

    Withania somnifera

    Stress/fatigue RCTs.

    Typical. Extract 300–600 mg.

    Safety. Pregnancy, thyroid, DILI.

  2. Asian ginseng (Panax ginseng)
    2
    Asian ginsengHuman data

    Panax ginseng

    Fatigue mixed data.

    Typical. Root extract 200–400 mg.

    Safety. Insomnia, INR, HTN.

Supportive plants1
  • American ginseng (Panax quinquefolius)
    American ginsengHuman data
    Panax quinquefolius

    Milder Panax relative; some fatigue/glucose data.

    Typical. Root 1–3 g.

    Safety. INR.

When this is not enough

  • Red-flag weight loss, lymphadenopathy, SI, syncope, chest pain

Rooted is a private clinical reference for licensed practitioners. It is educational, not a treatment protocol, and not a substitute for the chart, the exam, or pharmacy review. Plant medicines interact with drugs and can harm liver, kidney, heart, pregnancy, and children.

All other / general diagnoses