Piperaceae · fruit
Long pepper
Piper longum
Pippali — classical kindling and pranavaha pungent, constituent of Trikatu, Sitopaladi, and many guggulu yogas.
Safety first
Piperine-rich fruit. Stronger than black pepper in trikatu. Piperine can change drug absorption (CYP/P-gp stories). Pregnancy caution for medicinal doses. Culinary pinch is not a churna protocol.
Tradition vs trials
Traditional record. Ayurvedic Pharmacopoeia: pippali fruit as dipana, pachana, and rasayana-adjacent in specified yogas.
Trial literature. Human monotherapy outcome trials are not the mapping. Piperine bioavailability literature is the modern pharmacokinetic file.
Practical ranges
Educational ranges — not a prescription. Culinary use is not an extract.
fruit
Classical churna amounts in API yogas; not a prescription and not isolated piperine
Ayurvedic Pharmacopoeia of India — Educational range only — not a prescription. A licensed clinician individualizes product, dose, and duration.
Pregnancy, nursing, children
- Pregnancy. Avoid medicinal doses unless a clinician directs otherwise. Culinary traces are a different question.
- Nursing. Insufficient reliable data; avoid unless a clinician directs otherwise.
- Children. Insufficient reliable data; avoid unless a clinician directs otherwise.
Contraindications
- medicinal doses in pregnancy
- unsupervised stacking with narrow-index drugs
Key interactions
- CYP3A4 / P-gp substrates · caution
Piperine can raise levels of some drugs. A pharmacist reviews the actual list.