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Bitter orange (Citrus aurantium)

Rutaceae · fruit peel

Bitter orange

Citrus aurantium

Human clinical trialsRestricted / professional only

Peel is a traditional bitter and a modern synephrine supplement. This catalog maps the supplement object as restricted.

Safety first

p-Synephrine-containing extracts are pressor stimulants used in 'ephedra-free' weight-loss stacks. Combined with caffeine, MAOIs, or decongestants they are a cardiovascular problem. Culinary peel is not those extracts.

Tradition vs trials

Traditional record. TCM zhi shi / zhi ke neighborhood (related Citrus) and European bitter-peel bitters. Weight-loss extracts are a different object.

Trial literature. Synephrine plus caffeine has human pressor data. Weight-loss outcome data do not outrun the safety story.

Practical ranges

Educational ranges — not a prescription. Culinary use is not an extract.

  • extract

    No weight-loss range in this catalog

    NCCIH / FDA-era stimulant-stack notesEducational range only — not a prescription. A licensed clinician individualizes product, dose, and duration.

Pregnancy, nursing, children

  • Pregnancy. Avoid concentrated extracts.
  • Nursing. Avoid concentrated extracts.
  • Children. Not a pediatric stimulant.

Contraindications

  • ephedra-free weight-loss stacks
  • uncontrolled hypertension
  • MAOI therapy

Key interactions

  • stimulants / MAOIs / decongestants / uncontrolled hypertension · avoid

    Pressor stacking.

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